Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 16/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.56 |
| ▸ | LMNA | P02545 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 10/20 | 0.56 |
| ▸ | POLB | P06746 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | RECQL | P46063 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 13/20 | 0.54 |
| ▸ | HTT | P42858 | 11/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034031 | 1.00 | MAPT (0.56) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL4887343 | 0.81 | MAPT (0.57) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL11763015 | 0.81 | MAPT (0.57) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL4887344 | 0.81 | MAPT (0.57) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL1596707 | 0.77 | MAPT (0.71) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL1596704 | 0.77 | MAPT (0.71) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL99040 | 0.76 | MAPT (0.50) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL28006431 | 0.75 | MAPT (0.65) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL8991871 | 0.75 | MAPT (0.49) | MAPTALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL12218135 | 0.74 | MAPT (0.67) | MAPTALDH1A1KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| US-9085550-B2 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE (US) | 2015-07-21 | — | — | US | disclosed |
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-29 | — | — | US | disclosed |
| US-20130131340-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | FORMAN BARRY (US) | 2013-05-23 | — | — | US | disclosed |
| US-20090318693-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | FORMAN BARRY | 2009-12-24 | — | — | US | disclosed |
| US-7544838-B2 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE (US) | 2009-06-09 | — | — | US | disclosed |
| US-20060189825-A1 | Ligands for estrogen related receptors and methods for synthesis of said ligands | CITY OF HOPE | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | JAK2, ERBB2, CDC25C | MAPT 1483/4885ALDH1A1 3829/4885KMT2A 2419/4885 |
| US-20130131340-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | ESRRA, ESRRB, ESR2 | MAPT 4297/4885ALDH1A1 866/4885KMT2A 1373/4885 |
| US-20060189825-A1 | Ligands for estrogen related receptors and methods for synthesis of said ligands | ESRRA, ESRRB, ESR2 | MAPT 4297/4885ALDH1A1 866/4885KMT2A 1373/4885 |
| US-20090318693-A1 | LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS | ESRRA, ESRRB, ESR2 | MAPT 4297/4885ALDH1A1 866/4885KMT2A 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.