Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 19/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | LMNA | P02545 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 9/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 7/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 9/20 | 0.47 |
| ▸ | MITF | O75030 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99040 | 0.81 | MAPT (0.50) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL6261093 | 0.77 | MAPT (0.52) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL8138167 | 0.76 | MAPT (0.53) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL8138170 | 0.76 | MAPT (0.53) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL4887343 | 0.75 | MAPT (0.57) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL3978871 | 0.75 | MAPT (0.56) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL4887344 | 0.75 | MAPT (0.57) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL11482894 | 0.75 | MAPT (0.48) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL4034031 | 0.75 | MAPT (0.56) | MAPTALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL11763015 | 0.75 | MAPT (0.57) | MAPTALDH1A1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9795610-B2 | Theramutein modulators | Housey, Gerard M. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170191986-A1 | Compounds and Method of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HMI Medical Innovations, LLC | 2017-07-06 | — | — | US | disclosed |
| US-9645137-B2 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2017-05-09 | — | — | US | disclosed |
| US-20170112848-A1 | THERAMUTEIN MODULATORS | HMI Medical Innovations, LLC | 2017-04-27 | — | — | US | disclosed |
| US-9579326-B2 | Theramutein modulators | HMI Medical Innovations, LLC (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160153965-A1 | Compounds and Method of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HMI Medical Innovations, LLC | 2016-06-02 | — | — | US | disclosed |
| US-9222933-B2 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150133441-A1 | THERAMUTEIN MODULATORS | HMI MEDICAL INNOVATIONS, LLC. | 2015-05-14 | — | — | US | disclosed |
| US-20130150358-A1 | THERAMUTEIN MODULATORS | HMI MEDICAL INNOVATIONS, LLC. (US) | 2013-06-13 | — | — | US | disclosed |
| US-8431110-B2 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI MEDICAL INNOVATIONS, LLC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-8367038-B2 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI Medical Innovations, LLC (US) | 2013-02-05 | — | — | US | disclosed |
| EP-2447252-A2 | Theramutein modulators | Housey, Gerard M. (US) | 2012-05-02 | — | — | EP | disclosed |
| US-20100016298-A1 | Theramutein modulators | HOUSEY GERAD M | 2010-01-21 | — | — | US | disclosed |
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI MEDICAL INNOVATIONS, LLC. | 2008-10-30 | — | — | US | disclosed |
| WO-2007062213-A2 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HOUSEY PHARMACEUTICALS INC (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070111199-A1 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC | 2007-05-17 | — | — | US | disclosed |
| EP-0719796-A1 | Curable crosslinking system with monobenzaldimine as crosslinker | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1996-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016298-A1 | Theramutein modulators | TSG101, SERPINE1, PLAUR | MAPT 2984/4885ALDH1A1 4411/4885KMT2A 3567/4885 |
| US-20130150358-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | MAPT 2984/4885ALDH1A1 4411/4885KMT2A 3567/4885 |
| US-20150133441-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | MAPT 2984/4885ALDH1A1 4411/4885KMT2A 3567/4885 |
| US-20170112848-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | MAPT 2984/4885ALDH1A1 4411/4885KMT2A 3567/4885 |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | SERBP1, SERPINA6, UBE2V1 | MAPT 4644/4885ALDH1A1 3621/4885KMT2A 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.