Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 14/20 | 0.57 |
| ▸ | LMNA | P02545 | 12/20 | 0.57 |
| ▸ | HTT | P42858 | 11/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.56 |
| ▸ | MEN1 | O00255 | 13/20 | 0.56 |
| ▸ | POLB | P06746 | 9/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.56 |
| ▸ | RECQL | P46063 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 7/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11763015 | 1.00 | MAPT (0.57) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL4887343 | 1.00 | MAPT (0.57) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL3978871 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL99040 | 0.76 | MAPT (0.50) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL12443484 | 0.75 | MAPT (0.67) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL28006431 | 0.75 | MAPT (0.65) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL8991871 | 0.75 | MAPT (0.49) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL11482894 | 0.74 | MAPT (0.48) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL29957866 | 0.74 | MAPT (0.44) | MAPTSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL1596704 | 0.74 | MAPT (0.71) | MAPTSMN1; SMN2LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071650-B2 | Vanilloid receptor modulators; analgesic, antiinflammatory and antiulcer effects; such as 1-(1H-indol-5-ylmethyl)-3-phenethylthiourea | PACIFIC CORPORATION (KR) | 2011-12-06 | — | — | US | disclosed |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | SUH YOUNG G | 2008-03-13 | — | — | US | disclosed |
| CN-1186346-C | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2005-01-26 | — | — | CN | disclosed |
| EP-1301517-B1 | THIENOPYRROLIDINONES | HOFFMANN LA ROCHE (CH) | 2004-12-15 | — | — | EP | disclosed |
| EP-1303483-A4 | NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORP (KR) | 2004-11-03 | — | — | EP | disclosed |
| CN-1440412-A | Thienopyrrolidinones | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| US-20030153596-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | PACIFIC CORPORATION (KR) | 2003-08-14 | — | — | US | disclosed |
| EP-1303483-A1 | NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2003-04-23 | — | — | EP | disclosed |
| EP-1301517-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-6528653-B2 | E.g., 4,6-dihydro 4-(heterocyclic ring-methylene)thieno(2,3-b) pyrrolidin-5-one derivatives; tumor necrosis factor ) inhibitors; anticarcinogenic, -proliferative and -arthritic agents; Alzheimer's disease; cardiovascular disorders | HOFFMANN-LA ROCHE, INC. | 2003-03-04 | — | — | US | disclosed |
| US-20020028841-A1 | Thienopyrrolidinones | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | US | disclosed |
| WO-2002016318-A1 | NOVEL THIOUREA DERIVATIVES AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002002567-A1 | THIENOPYRROLIDINONES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |
| US-4061764-A | Certain O-substituted thiophene oxime carbamates used as antibacterial and antifungal agents | ABBOTT LABORATORIES (US) | 1977-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153596-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | TAS2R40, TAS1R2, TAS2R45 | MAPT 1674/4885SMN1; SMN2 2222/4885LMNA 4375/4885 |
| US-20080064687-A1 | Novel thiourea derivatives and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TAS2R5 | MAPT 3462/4885SMN1; SMN2 1383/4885LMNA 4716/4885 |
| US-20020028841-A1 | Thienopyrrolidinones | TNF, TYMP, TNFRSF1A | MAPT 1940/4885SMN1; SMN2 342/4885LMNA 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.