Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3975603 | 0.87 | PIP4K2A (0.49) | PIK3CABRAFPIP4K2APIP4K2CCAMKK2 | |
| SCHEMBL3977704 | 0.79 | PIK3CA (0.51) | PIK3CABRAFPIP4K2APIP4K2CCAMKK2 | |
| SCHEMBL3978660 | 0.75 | CAMKK2 (0.47) | BRAFCAMKK2ALDH1A1KDM4EPOLB | |
| SCHEMBL4188384 | 0.73 | BRAF (0.63) | PIK3CABRAFALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3978515 | 0.73 | PIK3CA (0.51) | PIK3CABRAFPIP4K2APIP4K2CALDH1A1 | |
| SCHEMBL4198556 | 0.73 | CNR1 (0.62) | BRAFKDM4ESMN1; SMN2HPGDRAB9A | |
| SCHEMBL4188391 | 0.72 | BRAF (0.61) | PIK3CABRAFPIP4K2APIP4K2CKDM4E | |
| SCHEMBL4199752 | 0.71 | BRAF (0.82) | PIK3CABRAFRAB9AMEN1KMT2A | |
| SCHEMBL4195978 | 0.71 | BRAF (0.76) | PIK3CABRAFALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4466113 | 0.70 | TEK (0.81) | PIP4K2CALDH1A1KDM4ESMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009059272-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | PIK3CA 59/4885BRAF 1/4885PIP4K2A 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.