Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229933 | 0.92 | CCR4 (0.35) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3982271 | 0.87 | F10 (0.41) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3377662 | 0.86 | HPGD (0.44) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3381006 | 0.85 | F10 (0.45) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3986630 | 0.82 | HTT (0.45) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL5780260 | 0.81 | HPGD (0.41) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3987347 | 0.81 | F10 (0.47) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL6404276 | 0.79 | F10 (0.43) | HPGDSMN1; SMN2ALDH1A1F10CCR4 | |
| SCHEMBL5779884 | 0.78 | F10 (0.40) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 | |
| SCHEMBL3984298 | 0.78 | F10 (0.63) | HPGDSMN1; SMN2ALDH1A1KMT2AF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029582-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |