Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | LAP3 | P28838 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718592 | 0.98 | CYP19A1 (0.39) | CYP19A1CYP11B1CYP11B2HTR2AHTR2C | |
| SCHEMBL9096104 | 0.86 | HTR2A (0.39) | CYP19A1HTR2AHTR2CDRD2DRD3 | |
| SCHEMBL2730840 | 0.83 | HTR2A (0.47) | CYP11B1CYP11B2HTR2AHTR2CHTR2B | |
| SCHEMBL23792237 | 0.80 | CYP11B2 (0.47) | CYP19A1CYP11B1CYP11B2HTR2AHTR2C | |
| SCHEMBL206438 | 0.76 | PARP10 (0.49) | CYP19A1CYP11B1CYP11B2SLC11A2CYP26A1 | |
| SCHEMBL8749446 | 0.76 | PARP10 (0.49) | CYP19A1CYP11B1CYP11B2SLC11A2CYP26A1 | |
| SCHEMBL11828763 | 0.74 | PARP10 (0.47) | MAOAMAOBCYP26A1 | |
| SCHEMBL26705589 | 0.74 | DRD2 (0.46) | CYP19A1CYP11B1CYP11B2HTR2AHTR2C | |
| SCHEMBL11566215 | 0.74 | DRD2 (0.43) | HTR2AHTR2CHTR2BDRD2DRD3 | |
| SCHEMBL5989642 | 0.74 | CYP26A1 (0.57) | CYP19A1DRD2DRD3MIFMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054410-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | Wyeth (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008021331-A2 | OXAZOLIDONE DERIVATIVES AS PR MODULATORS | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |