Known targets — ChEMBL curated mechanism
PDE10APDE1APDE1BPDE1CPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6APDE6BPDE6CPDE6DPDE6GPDE6HPDE7APDE7BPDE8APDE8BPDE9ASLC29A1
The experimentally established mechanism targets of Dipyridamole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 known ✓ | Q99808 | 19/20 | 1.00 |
| ▸ | PDE2A known ✓ | O00408 | 1/20 | 1.00 |
| ▸ | PDE6D known ✓ | O43924 | 1/20 | 1.00 |
| ▸ | PDE8A known ✓ | O60658 | 1/20 | 1.00 |
| ▸ | PDE5A known ✓ | O76074 | 1/20 | 1.00 |
| ▸ | PDE6A known ✓ | P16499 | 1/20 | 1.00 |
| ▸ | PDE6G known ✓ | P18545 | 1/20 | 1.00 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 1.00 |
| ▸ | PDE6B known ✓ | P35913 | 1/20 | 1.00 |
| ▸ | PDE6C known ✓ | P51160 | 1/20 | 1.00 |
| ▸ | PDE1A known ✓ | P54750 | 1/20 | 1.00 |
| ▸ | PDE1B known ✓ | Q01064 | 1/20 | 1.00 |
| ▸ | PDE4B known ✓ | Q07343 | 1/20 | 1.00 |
| ▸ | PDE4C known ✓ | Q08493 | 1/20 | 1.00 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 1.00 |
| ▸ | PDE3B known ✓ | Q13370 | 1/20 | 1.00 |
| ▸ | PDE7A known ✓ | Q13946 | 1/20 | 1.00 |
| ▸ | PDE6H known ✓ | Q13956 | 1/20 | 1.00 |
| ▸ | PDE1C known ✓ | Q14123 | 1/20 | 1.00 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridamole SCHEMBL16119 | 1.00 | SLC29A1 (1.00) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL9743915 | 0.98 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL7362290 | 0.98 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL7998210 | 0.98 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL17044166 | 0.97 | SLC29A1 (0.94) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL611283 | 0.95 | SLC29A1 (0.91) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| SCHEMBL17017272 | 0.93 | SLC29A1 (0.86) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL11234613 | 0.93 | SLC29A1 (0.86) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| SCHEMBL6915061 | 0.93 | SLC29A1 (0.86) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| SCHEMBL5055565 | 0.93 | SLC29A1 (0.86) | SLC29A1ADORA3KDM4EMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108059633-B | Synthesis method of dipyridamole intermediate | 南京杰运医药科技有限公司 | 2020-09-04 | — | — | CN | disclosed |
| CN-110876767-A | Medicine for preventing and treating cardiovascular and cerebrovascular diseases and apoplexy sequela | 刘延领 | 2020-03-13 | — | — | CN | disclosed |
| CN-105106225-A | Compound dipyridamole and aspirin tablet and preparation method thereof | HEBEI ZHITONG PHARMACEUTICAL GROUP CO LTD | 2015-12-02 | — | — | CN | disclosed |
| EP-1768660-A4 | COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES | ATHEROGENICS INC (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2007041593-A2 | ANTI-SCARRING DRUG COMBINATIONS AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041463-A2 | ELECTRICAL DEVICES AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1768660-A2 | COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES | Atherogenics, Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006007508-A2 | COMPOUNDS AND METHODS FOR TREATING DIABETIC VASCULAR DISEASES | ATHEROGENICS, INC. (US) | 2006-01-19 | — | — | WO | disclosed |
| US-5314688-A | Local delivery of dipyridamole for the treatment of proliferative diseases | ELI LILLY AND COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| US-5270047-A | Local delivery of dipyridamole for the treatment of proliferative diseases | ELI LILLY AND COMPANY | 1993-12-14 | — | — | US | disclosed |