Known targets — ChEMBL curated mechanism
PDE10APDE1APDE1BPDE1CPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6APDE6BPDE6CPDE6DPDE6GPDE6HPDE7APDE7BPDE8APDE8BPDE9ASLC29A1
The experimentally established mechanism targets of Dipyridamole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 known ✓ | Q99808 | 19/20 | 0.94 |
| ▸ | PDE2A known ✓ | O00408 | 1/20 | 0.94 |
| ▸ | PDE6D known ✓ | O43924 | 1/20 | 0.94 |
| ▸ | PDE8A known ✓ | O60658 | 1/20 | 0.94 |
| ▸ | PDE5A known ✓ | O76074 | 1/20 | 0.94 |
| ▸ | PDE6A known ✓ | P16499 | 1/20 | 0.94 |
| ▸ | PDE6G known ✓ | P18545 | 1/20 | 0.94 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.94 |
| ▸ | PDE6B known ✓ | P35913 | 1/20 | 0.94 |
| ▸ | PDE6C known ✓ | P51160 | 1/20 | 0.94 |
| ▸ | PDE1A known ✓ | P54750 | 1/20 | 0.94 |
| ▸ | PDE1B known ✓ | Q01064 | 1/20 | 0.94 |
| ▸ | PDE4B known ✓ | Q07343 | 1/20 | 0.94 |
| ▸ | PDE4C known ✓ | Q08493 | 1/20 | 0.94 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.94 |
| ▸ | PDE3B known ✓ | Q13370 | 1/20 | 0.94 |
| ▸ | PDE7A known ✓ | Q13946 | 1/20 | 0.94 |
| ▸ | PDE6H known ✓ | Q13956 | 1/20 | 0.94 |
| ▸ | PDE1C known ✓ | Q14123 | 1/20 | 0.94 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridamole SCHEMBL16119 | 0.97 | SLC29A1 (1.00) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL3980595 | 0.97 | SLC29A1 (1.00) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| SCHEMBL30416820 | 0.97 | SLC29A1 (1.00) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL29381078 | 0.97 | SLC29A1 (1.00) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL611283 | 0.95 | SLC29A1 (0.91) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL7362290 | 0.95 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL29002462 | 0.95 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL9743915 | 0.95 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL7998210 | 0.95 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A | |
| Dipyridamole SCHEMBL28672572 | 0.95 | SLC29A1 (0.97) | SLC29A1ADORA3KDM4EMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100480697-C | Quality control method for injection containing breviscapini and dipyridamole | GUIYANG YUNYAN XICHUANG PHARM (CN) | 2009-04-22 | — | — | CN | claimed |
| WO-2023079290-A1 | DRUG COATED BALLOON | ARTERIUS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |
| EP-2296685-B1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | SYNERGY PHARMACEUTICALS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| CN-100480697-C | Quality control method for injection containing breviscapini and dipyridamole | GUIYANG YUNYAN XICHUANG PHARM (CN) | 2009-04-22 | — | — | CN | disclosed |
| CN-1808114-A | Quality control method for injection containing breviscapini and dipyridamole | GUIYANG YUNYAN XICHUANG PHARM (CN) | 2006-07-26 | — | — | CN | disclosed |