Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4B | O94953 | 1/20 | 0.50 |
| ▸ | KDM5C | P41229 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 4/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038517 | 0.77 | KDM5C (0.69) | KDM4BKDM5CKDM5BMAP4K4PARP1 | |
| SCHEMBL23458742 | 0.75 | KDM5C (0.48) | KDM4BKDM5CKDM5BMAP4K4PARP1 | |
| SCHEMBL15754359 | 0.75 | IDO1 (0.44) | IDO1JAK2GCKALDH1A1 | |
| SCHEMBL23458760 | 0.73 | KDM4B (0.47) | KDM4BKDM5CKDM5BMAP4K4PARP1 | |
| SCHEMBL46849 | 0.73 | PARP10 (0.49) | KDM4BKDM5CKDM5BMAP4K4KDM4C | |
| SCHEMBL25279052 | 0.73 | KMO (0.61) | KDM4BKDM5CKDM5BKDM4CKDM4E | |
| SCHEMBL19596372 | 0.72 | KMT2A (0.54) | PARP1KDM4EALDH1A1 | |
| SCHEMBL23458438 | 0.72 | KDM4B (0.46) | KDM4BKDM5CKDM5BMAP4K4PARP1 | |
| SCHEMBL29933213 | 0.72 | HDAC1 (0.58) | KDM4BKDM5CKDM5BMAP4K4PARP1 | |
| SCHEMBL2403689 | 0.72 | KDM4C (0.69) | KDM5CKDM5BKDM4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |