Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL5162028 | 0.86 | CA5A (0.80) | — | |
| Nitric Acid SCHEMBL13560601 | 0.86 | — | — | |
| Nitric Acid SCHEMBL28411161 | 0.85 | CA5A (1.00) | — | |
| Nitric Acid SCHEMBL3762342 | 0.85 | CA5A (1.00) | — | |
| Nitric Acid SCHEMBL10981408 | 0.85 | — | — | |
| Nitric Acid SCHEMBL7750558 | 0.85 | — | — | |
| Nitric Acid SCHEMBL302522 | 0.85 | CA5A (1.00) | — | |
| Nitric Acid SCHEMBL234 | 0.85 | — | — | |
| Nitric Acid SCHEMBL37356 | 0.85 | — | — | |
| Nitric Acid SCHEMBL8383283 | 0.85 | CA5A (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524076-A | Diazeniumdiolate nitric oxide-donating type oridonin derivatives, preparation method and application | UNIV CHINA PHARMA | 2016-04-27 | — | — | CN | disclosed |
| US-9095734-B2 | Nitric oxide releasing multifunctional polymers | Maple Ridge Group, LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-8894985-B2 | Nitric oxide-releasing polymers | AMULET PHARMACEUTICALS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140271523-A1 | Nitric Oxide Releasing Multifunctional Polymers | Maple Ridge Group, LLC (US) | 2014-09-18 | — | — | US | disclosed |
| US-8101589-B2 | Nitric oxide-releasing molecules | NOXILIZER, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110059036-A1 | NITRIC OXIDE-RELEASING POLYMERS | AMULET PHARMACEUTICALS, INC. | 2011-03-10 | — | — | US | disclosed |
| US-7829553-B2 | generation of NO from a C-based diazeniumdiolate that is covalently attached to a phenyl-containing polymer( polystyrene homo or copolymer, polyethyene terephthalate, polyamides etc.) without the possibility to form nitrosamines; of vascular stents, vascular grafts, catheters, wound dressings, bandages | AMULET PHARMACEUTICALS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20090270509-A1 | NITRIC OXIDE-RELEASING MOLECULES | NOXILIZER, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-7569559-B2 | Nitric oxide-releasing molecules | NOXILIZER, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| EP-1968615-A1 | NITRIC OXIDE-RELEASING POLYMERS | Amulet Pharmaceuticals, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| US-20070286840-A1 | generation of NO from a C-based diazeniumdiolate that is covalently attached to a phenyl-containing polymer( polystyrene homo or copolymer, polyethyene terephthalate, polyamides etc.) without the possibility to form nitrosamines; of vascular stents, vascular grafts, catheters, wound dressings, bandages | AMULET PHARMACEUTICALS, INC. | 2007-12-13 | — | — | US | disclosed |
| US-20070196327-A1 | Nitric oxide releasing polymers | AMULET PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007067477-A1 | NITRIC OXIDE-RELEASING POLYMERS | AMULET PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| EP-1718316-A2 | NITRIC OXIDE-RELEASING POLYMERS | Amulet Pharmaceuticals, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| EP-1718603-A2 | NITRIC OXIDE-RELEASING MOLECULES | Noxilizer, Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| US-20050203069-A1 | Nitric oxide-releasing molecules | NOXILIZER, INC. | 2005-09-15 | — | — | US | disclosed |
| WO-2005081752-A2 | NITRIC OXIDE-RELEASING POLYMERS | AMULET PHARMACEUTICALS, INC. (US) | 2005-09-09 | — | — | WO | disclosed |
| WO-2005081753-A2 | NITRIC OXIDE-RELEASING MOLECULES | NOXILIZER, INC. (US) | 2005-09-09 | — | — | WO | disclosed |