Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.34 |
| ▸ | TUBB | P07437 | 4/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isothiazole SCHEMBL3981927 | 0.83 | NEK2 (0.38) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| Isothiazole SCHEMBL3982389 | 0.81 | TUBB4A (0.36) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| Isothiazole SCHEMBL3984653 | 0.80 | FYN (0.34) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL617920 | 0.72 | TUBB4A (0.44) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL617386 | 0.70 | TUBB4A (0.43) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL4651028 | 0.68 | ACHE (0.46) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL15159032 | 0.65 | TUBB4A (0.37) | ALDH1A1MAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL13593082 | 0.64 | TUBB4A (0.61) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL1168756 | 0.64 | MEN1 (0.43) | SMN1; SMN2ALDH1A1KMT2AKDM4EMEN1 | |
| Isothiazole SCHEMBL3985152 | 0.64 | NEK2 (0.38) | ALDH1A1KMT2AKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059250-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Synta Pharmaceuticals Corporation (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008033449-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-20 | — | — | WO | disclosed |