Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 10/20 | 0.69 |
| ▸ | BCL2A1 | Q16548 | 8/20 | 0.69 |
| ▸ | METAP2 | P50579 | 6/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097689 | 0.88 | METAP2 (0.66) | MCL1BCL2A1METAP2ALDH1A1 | |
| SCHEMBL18151871 | 0.82 | MCL1 (1.00) | MCL1BCL2A1METAP2BCL2BCL2L1 | |
| SCHEMBL2009251 | 0.81 | METAP2 (1.00) | MCL1BCL2A1METAP2GAAHPGD | |
| SCHEMBL16495860 | 0.81 | METAP2 (0.73) | MCL1BCL2A1METAP2ACLY | |
| SCHEMBL18151872 | 0.81 | MCL1 (1.00) | MCL1BCL2A1METAP2BCL2BCL2L1 | |
| SCHEMBL4565923 | 0.79 | METAP2 (0.69) | MCL1BCL2A1METAP2ACLY | |
| SCHEMBL1139356 | 0.78 | ACLY (0.78) | METAP2ACLY | |
| SCHEMBL18164449 | 0.78 | MCL1 (0.80) | MCL1BCL2A1METAP2GAABCL2 | |
| SCHEMBL3979169 | 0.78 | METAP2 (1.00) | MCL1BCL2A1METAP2GAACYP1A2 | |
| SCHEMBL3988425 | 0.78 | METAP2 (0.68) | MCL1BCL2A1METAP2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491718-B2 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES (US) | 2009-02-17 | — | — | US | disclosed |
| EP-1549613-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | Abbott Laboratories (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20040167128-A1 | Sulfonamides having antiangiogenic and anticancer activity | ABBVIE INC. | 2004-08-26 | — | — | US | disclosed |
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES | 2004-08-12 | — | — | US | disclosed |
| WO-2004033419-A1 | SULFONAMIDES HAVING ANTIANGIOGENIC AND ANTICANCER ACTIVITY | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167128-A1 | Sulfonamides having antiangiogenic and anticancer activity | METAP2, METAP1, DNPEP | MCL1 1545/4885BCL2A1 1450/4885METAP2 1/4885 |
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | METAP2, METAP1, DNPEP | MCL1 1545/4885BCL2A1 1450/4885METAP2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.