Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.53 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039982 | 0.90 | CCR2 (0.58) | MRGPRX1CCR2CCR1CCR5CYP2C9 | |
| SCHEMBL3982945 | 0.89 | MRGPRX1 (0.50) | MRGPRX1CCR2ST14F2PRSS1 | |
| SCHEMBL3054529 | 0.84 | CCR2 (0.47) | MRGPRX1CCR2PTGDR2CCR1CCR5 | |
| SCHEMBL3049477 | 0.83 | CCR2 (0.62) | MRGPRX1CCR2ST14F2PRSS1 | |
| SCHEMBL3052348 | 0.80 | CCR2 (0.45) | MRGPRX1CCR2PTGDR2CCR1CCR5 | |
| SCHEMBL3050565 | 0.80 | CCR2 (0.64) | CCR2PTGDR2CCR1CCR5ALDH1A1 | |
| SCHEMBL3274441 | 0.77 | CCR2 (0.50) | MRGPRX1CCR2PTGDR2CCR1CCR5 | |
| SCHEMBL3274401 | 0.77 | POLB (0.72) | MRGPRX1CCR2POLBPTGDR2CCR1 | |
| SCHEMBL3140026 | 0.76 | CCR2 (0.45) | MRGPRX1CCR2CYP2C9ALDH1A1KDM4E | |
| SCHEMBL3054749 | 0.76 | CCR1 (0.54) | CCR2POLBPTGDR2CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057116-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008050167-A1 | NEW PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-05-02 | — | — | WO | disclosed |