Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.58 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | CCR1 | P32246 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897956 | 0.89 | CCR1 (0.60) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL4043636 | 0.87 | PTGDR2 (0.57) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL3049525 | 0.85 | CACNA1H (0.56) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL3049521 | 0.85 | POLB (0.53) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL5458136 | 0.84 | POLB (1.00) | POLBL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3050790 | 0.82 | PTPN1 (0.61) | CACNA1HCACNA1BCCR1CCR2TDP1 | |
| SCHEMBL3047854 | 0.82 | PTGDR2 (0.57) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL3757218 | 0.81 | POLB (0.55) | POLBPTGDR2CACNA1HCACNA1BCCR1 | |
| SCHEMBL3148243 | 0.81 | CCR2 (0.70) | CCR1CCR2 | |
| SCHEMBL3054749 | 0.81 | CCR1 (0.54) | POLBPTGDR2CACNA1HCACNA1BCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481527-B2 | Benzamide derivatives as bradykinin antagonists | RICHTER GEDEON NYRT. (HU) | 2013-07-09 | — | — | US | disclosed |
| US-20100087423-A1 | NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2010-04-08 | — | — | US | disclosed |
| EP-2076491-A1 | NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | Richter Gedeon NYRT (HU) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008068540-A1 | NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | RICHTER GEDEON NYRT. (HU) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087423-A1 | NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS | BDKRB1, BDKRB2, HRH1 | POLB 3375/4885PTGDR2 195/4885CACNA1H 997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.