Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.65 |
| ▸ | NAAA | Q02083 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267484 | 0.98 | HSD17B3 (0.66) | HSD17B3NAAAHTR7HRH2HRH1 | |
| SCHEMBL29959715 | 0.98 | HSD17B3 (0.66) | HSD17B3NAAAHTR7HRH2HRH1 | |
| SCHEMBL9440245 | 0.98 | HSD17B3 (0.66) | HSD17B3NAAAHTR7HRH2HRH1 | |
| SCHEMBL9146061 | 0.98 | HSD17B3 (0.66) | HSD17B3NAAAHTR7HRH2HRH1 | |
| SCHEMBL7220547 | 0.94 | HSD17B3 (0.63) | HSD17B3NAAAHTR7HRH2HRH1 | |
| Propyl 4-Pyridyl Ketone SCHEMBL4952700 | 0.86 | HSD17B3 (0.61) | HSD17B3NAAAHTR7ALPIHDAC3 | |
| SCHEMBL18753070 | 0.86 | HSD17B3 (0.84) | HSD17B3HTR7STSNPC1LMNA | |
| SCHEMBL13085847 | 0.84 | HSD17B3 (0.85) | HSD17B3HTR7STSLMNA | |
| SCHEMBL13085794 | 0.84 | HSD17B3 (0.85) | HSD17B3HTR7STSLMNA | |
| Hexane SCHEMBL20446667 | 0.82 | NAAA (0.47) | HSD17B3NAAAHRH2HRH1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183004-B2 | Determination of short-chain SRL alcohol dehydrogenase (DHRS4) as a biomarker for inflammations and infections | B.R.A.H.M.S GMBH (DE) | 2012-05-22 | — | — | US | disclosed |
| US-20090136973-A1 | DETERMINATION OF SHORT-CHAIN SRL ALCOHOL DEHYDROGENASE (DHRS4) AS A BIOMARKER FOR INFLAMMATIONS AND INFECTIONS | B.R.A.H.M.S AKTIENGESELLSCHAFT (DE) | 2009-05-28 | — | — | US | disclosed |
| EP-1856538-B1 | DETERMINATION OF SHORT-CHAIN SRL-ALCOHOL DEHYDROGENASE (DHRS4) AS BIOMARKER OF INFLAMMATIONS AND INFECTIONS | BRAHMS AG (DE) | 2009-05-13 | — | — | EP | disclosed |
| CN-100448846-C | Method for catalytic hydrogenation of acyl pyridine to preparing substituted pyridine compound hydrochlorate | UNIV TSINGHUA (CN) | 2009-01-07 | — | — | CN | disclosed |
| EP-1856538-A1 | DETERMINATION OF SHORT-CHAIN SRL-ALCOHOL DEHYDROGENASE (DHRS4) AS BIOMARKER OF INFLAMMATIONS AND INFECTIONS | BRAHMS Aktiengesellschaft (DE) | 2007-11-21 | — | — | EP | disclosed |
| CN-1995017-A | Method for catalytic hydrogenation of acyl pyridine to preparing substituted pyridine compound hydrochlorate | UNIV TSINGHUA (CN) | 2007-07-11 | — | — | CN | disclosed |
| WO-2006094747-A1 | DETERMINATION OF SHORT-CHAIN SRL-ALCOHOL DEHYDROGENASE (DHRS4) AS BIOMARKER OF INFLAMMATIONS AND INFECTIONS | B.R.A.H.M.S AKTIENGESELLSCHAFT (DE) | 2006-09-14 | — | — | WO | disclosed |