Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978507 | 0.85 | USP30 (0.47) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL3986036 | 0.83 | GRIN2B (0.48) | KDM4ETSHRHSD17B10CKS1BSKP1 | |
| SCHEMBL5085870 | 0.83 | PTGS2 (0.47) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL3983755 | 0.82 | KDM4E (0.43) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL3979867 | 0.81 | KDM4E (0.51) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL5083458 | 0.80 | GPR119 (0.60) | GPR119 | |
| SCHEMBL5083434 | 0.80 | KDM4E (0.52) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL3982989 | 0.79 | KDM4E (0.48) | KDM4ETSHRHSD17B10USP30PTGS2 | |
| SCHEMBL3983386 | 0.78 | GPR119 (0.56) | KDM4ETSHRHSD17B10GPR119 | |
| SCHEMBL3980600 | 0.77 | GRIN2B (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059516-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (publ) (SE) | 2009-05-20 | — | — | EP | claimed |
| WO-2008025798-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2008-03-06 | — | — | WO | claimed |