Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086233 | 0.85 | GPR119 (0.52) | USP30GPR119 | |
| SCHEMBL3984090 | 0.85 | CXCR4 (0.42) | NPC1RAB9ASMN1; SMN2HPGDSTP53 | |
| SCHEMBL5083436 | 0.76 | USP30 (0.45) | HPGDSUSP30GPR119 | |
| SCHEMBL1346051 | 0.76 | KDM1A (0.47) | HPGDSCYP11B1CYP11B2 | |
| SCHEMBL1347367 | 0.76 | KDM1A (0.47) | HPGDSCYP11B1CYP11B2 | |
| SCHEMBL1346050 | 0.76 | KDM1A (0.47) | HPGDSCYP11B1CYP11B2 | |
| SCHEMBL3984556 | 0.75 | KDM1A (0.47) | HPGDSCYP11B1CYP11B2DRD4CXCR4 | |
| SCHEMBL3985778 | 0.75 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HPGDSTP53 | |
| SCHEMBL1348274 | 0.73 | KDM1A (0.49) | HPGDSCYP11B1CYP11B2CHEK1 | |
| SCHEMBL3987206 | 0.72 | GPR119 (0.53) | MTORGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059516-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (publ) (SE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008025798-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2008-03-06 | — | — | WO | disclosed |