Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3981222 | 0.84 | SSTR4 (0.40) | KCNH2SLC2A1SSTR1 | |
| SCHEMBL3090361 | 0.84 | SSTR4 (0.40) | KCNH2SLC2A1SSTR1 | |
| SCHEMBL3095797 | 0.84 | SSTR4 (0.40) | KCNH2SLC2A1SSTR1 | |
| SCHEMBL3107031 | 0.83 | SPHK1 (0.37) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 | |
| Hydrochloric Acid SCHEMBL3107676 | 0.83 | SLC2A1 (0.38) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 | |
| SCHEMBL3106752 | 0.81 | OPRM1 (0.35) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 | |
| SCHEMBL6079762 | 0.80 | CNR2 (0.45) | KCNH2SIGMAR1SLC2A1UBE2MDCUN1D1 | |
| SCHEMBL3982792 | 0.80 | KCNH2 (0.37) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 | |
| SCHEMBL3982714 | 0.79 | PTPN11 (0.35) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 | |
| SCHEMBL3100022 | 0.79 | PTPN11 (0.35) | KCNH2SLC2A1HTR1AHTR1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029612-A1 | SUBSTITUTED 1-METHYL-1H-QUINOLIN-2-ONES AND 1-METHYL-1H-1,5-NAPHTHYRIDIN-2-ONES AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008006648-A1 | SUBSTITUTED 1-METHYL-1H-QUINOLIN-2-ONES AND 1-METHYL-1H-1,5-NAPHTHYRIDIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |