Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | IL1R1 | P14778 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994167 | 0.83 | BRD4 (0.43) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL27743828 | 0.83 | BRD4 (0.43) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL8976521 | 0.82 | BRD4 (0.48) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL5776962 | 0.81 | NR4A2 (0.51) | BRD4TDO2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13828379 | 0.80 | L3MBTL1 (0.48) | BRD4BRD2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5773143 | 0.80 | FFAR4 (0.51) | ALDH1A1MAPTHDAC1GAAHPGD | |
| SCHEMBL3075233 | 0.79 | ALDH1A1 (0.48) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL244016 | 0.79 | BRD4 (0.46) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL2413945 | 0.79 | BRD4 (0.46) | BRD4TDO2BRD2ALDH1A1MAPT | |
| SCHEMBL14792983 | 0.77 | ALDH1A1 (0.46) | BRD4TDO2BRD2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059502-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008011392-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACUETICALS INCORPORATED (US) | 2008-01-24 | — | — | WO | disclosed |