Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | MAT2A | P31153 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985869 | 0.80 | ELANE (0.56) | ELANEMAT2AHSD17B10 | |
| SCHEMBL1005780 | 0.75 | HTR3A (0.49) | PIK3CA | |
| SCHEMBL1006741 | 0.75 | HTR3A (0.49) | PIK3CA | |
| SCHEMBL1003484 | 0.74 | ELANE (0.50) | ELANEHSD17B10 | |
| SCHEMBL1003486 | 0.74 | ELANE (0.50) | ELANEHSD17B10 | |
| SCHEMBL3984179 | 0.73 | HTR3A (0.35) | ALDH1A1POLB | |
| SCHEMBL1004322 | 0.73 | HTR3A (0.51) | PIK3CARAB9ANPC1 | |
| SCHEMBL1005156 | 0.73 | HTR3A (0.51) | PIK3CARAB9ANPC1 | |
| SCHEMBL1006071 | 0.72 | HTR3A (0.51) | ALDH1A1POLB | |
| SCHEMBL1006356 | 0.72 | HTR3A (0.52) | ALDH1A1PIK3CDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |