Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547313 | 0.80 | PGR (0.49) | PGRKIF11KMT2ACYP3A4MAPK1 | |
| SCHEMBL4961089 | 0.80 | PGR (0.49) | PGRKIF11KMT2ACYP3A4MAPK1 | |
| SCHEMBL547466 | 0.80 | PGR (0.49) | PGRKIF11KMT2ACYP3A4MAPK1 | |
| SCHEMBL3990955 | 0.78 | KCNH2 (0.36) | MAPTKDM4EGLAPTGDR2HDAC6 | |
| SCHEMBL78315 | 0.78 | PGR (0.49) | MAPTPOLBKDM4EGLAPTGDR2 | |
| SCHEMBL30788045 | 0.78 | PGR (0.49) | MAPTPOLBKDM4EGLAPTGDR2 | |
| SCHEMBL10709575 | 0.78 | KMT2A (0.41) | MAPTPGRHSP90AA1HSP90AB1KMT2A | |
| SCHEMBL3984941 | 0.77 | SMN1; SMN2 (0.42) | MAPTPOLBKDM4EGLAHDAC6 | |
| SCHEMBL3983090 | 0.75 | HDAC1 (0.36) | MAPTPOLBKDM4EGLAHDAC2 | |
| SCHEMBL3985076 | 0.75 | MAPT (0.38) | MAPTPOLBKDM4EGLAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598237-B2 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2009-10-06 | — | — | US | disclosed |
| US-20080139530-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives And Their Use As Progesterone Receptor Modulators | WYETH (US) | 2008-06-12 | — | — | US | disclosed |
| US-20080113964-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators | WYETH (US) | 2008-05-15 | — | — | US | disclosed |
| US-7323455-B2 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2008-01-29 | — | — | US | disclosed |
| US-20050215539-A1 | 7-aryl 1,5-dihydro-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | WYETH (US) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113964-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives and Their Use As Progesterone Receptor Modulators | PGR, GPER1, PGRMC2 | MAPT 3953/4885POLB 4770/4885KDM4E 859/4885 |
| US-20080139530-A1 | 7-Aryl 1,5-Dihydro-4,1-Benzoxazepin-2(3H)-One Derivatives And Their Use As Progesterone Receptor Modulators | PGR, GPER1, PGRMC2 | MAPT 3953/4885POLB 4770/4885KDM4E 859/4885 |
| US-20050215539-A1 | 7-aryl 1,5-dihydro-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators | PGR, GPER1, PGRMC2 | MAPT 3953/4885POLB 4770/4885KDM4E 859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.