Sugi Predict

Sugi Predict / Compounds / SCHEMBL78315

SCHEMBL78315

SCHEMBL78315

CC(C)(O)c1cc(Br)ccc1N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 1/20 0.49
▸ KDM4E B2RXH2 2/20 0.42
▸ GLA P06280 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPT P10636 4/20 0.39
▸ POLB P06746 1/20 0.38
▸ PLAU P00749 1/20 0.37
▸ PTGDR2 Q9Y5Y4 1/20 0.37
▸ NPC1 O15118 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ AR P10275 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ FFAR1 O14842 1/20 0.33
▸ FFAR4 Q5NUL3 1/20 0.33
▸ DGAT1 O75907 1/20 0.33
▸ HDAC1 Q13547 1/20 0.33
▸ KDM1A O60341 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30788045 1.00 PGR (0.49) PGRKDM4EGLASMN1; SMN2MAPT
SCHEMBL15210675 0.85 KDM4E (0.39) PGRKDM4EGLASMN1; SMN2MAPT
SCHEMBL381761 0.83 PTGDR2 (0.42) KDM4EGLASMN1; SMN2MAPTPOLB
SCHEMBL7847441 0.80 PTGDR2 (0.40) PTGDR2NPC1MAPK1HTTALDH1A1
SCHEMBL4126225 0.79 KDM4E (0.39) PGRKDM4EGLASMN1; SMN2MAPT
SCHEMBL28201831 0.78 PGR (0.51) PGRGLASMN1; SMN2MAPTPOLB
SCHEMBL3984867 0.78 MAPT (0.42) PGRKDM4EGLASMN1; SMN2MAPT
SCHEMBL19411767 0.77 AAK1 (0.38) PGRKDM4EGLASMN1; SMN2MAPT
SCHEMBL25593793 0.77 PTGDR2 (0.38) PGRMAPTPOLBPTGDR2MAPK1
SCHEMBL3291266 0.77 SMN1; SMN2 (0.63) PGRSMN1; SMN2MAPTPOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240383870-A1 HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF ALDEYRA THERAPEUTICS, INC. 2024-11-21 — — US disclosed
EP-4362930-A1 HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF Aldeyra Therapeutics, Inc. (US) 2024-05-08 — — EP disclosed
CN-117580569-A Heterocyclic aldehyde capture compounds and uses thereof 奥尔德拉医疗公司 2024-02-20 — — CN disclosed
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-11724987-B2 Compositions and methods of treating retinal disease ALDEYRA THERAPEUTICS, INC. (US) 2023-08-15 — — US disclosed
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-08-10 — — US disclosed
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS ALDEYRA THERAPEUTICS, INC. 2023-08-10 — — US disclosed
US-11583529-B2 Treatment of inflammatory disorders ALDEYRA THERAPEUTICS, INC. (US) 2023-02-21 — — US disclosed
WO-2023278816-A1 HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF ALDEYRA THERAPEUTICS, INC. (US) 2023-01-05 — — WO disclosed
EP-1173433-A1 CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS American Home Products Corporation (US) 2002-01-23 — — EP disclosed
EP-1173206-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING QUINAZOLINONE AND BENZOXAZINE DERIVATIVES American Home Products Corporation (US) 2002-01-23 — — EP disclosed
EP-1173426-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS American Home Products Corporation (US) 2002-01-23 — — EP disclosed
EP-1173210-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC American Home Products Corporation (US) 2002-01-23 — — EP disclosed
WO-2000066560-A1 QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed
WO-2000066165-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed
WO-2000066581-A1 CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed
WO-2000066570-A1 CYCLOTHIOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed
WO-2000066164-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING ANTIPROGESTINIC AND PROGESTINIC AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed
WO-2000066571-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11724987-B2 Compositions and methods of treating retinal disease ALDH1A2, PLA2G2E, CLN6 PGR 3677/4885KDM4E 4260/4885GLA 190/4885
US-20230293527-A1 TREATMENT OF INFLAMMATORY DISORDERS TNF, NFKBIA, LTB4R2 PGR 1434/4885KDM4E 4467/4885GLA 698/4885
US-11583529-B2 Treatment of inflammatory disorders TNF, NFKBIA, LTB4R2 PGR 1434/4885KDM4E 4467/4885GLA 698/4885
US-20230248727-A1 TREATMENT OF INFLAMMATORY DISORDERS TNF, NFKBIA, LTB4R2 PGR 1434/4885KDM4E 4467/4885GLA 698/4885
US-20240383870-A1 HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF ALDH1A2, ALDH2, SSB PGR 4880/4885KDM4E 1666/4885GLA 668/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.