Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16654817 | 0.89 | MAPT (0.57) | MAPTSIRT6LMNARECQLHPGD | |
| SCHEMBL77148 | 0.84 | SIRT6 (1.00) | MAPTSIRT6LMNARECQLALDH1A1 | |
| SCHEMBL11296150 | 0.83 | MAPT (0.50) | MAPTSIRT6LMNAHPGDKMT2A | |
| SCHEMBL11371732 | 0.83 | SIRT6 (0.53) | MAPTSIRT6LMNAHPGDKMT2A | |
| SCHEMBL3109069 | 0.82 | LMNA (1.00) | MAPTSIRT6LMNARECQLHPGD | |
| SCHEMBL30059159 | 0.82 | LMNA (1.00) | MAPTSIRT6LMNARECQLHPGD | |
| SCHEMBL25877527 | 0.82 | LMNA (0.94) | MAPTSIRT6LMNARECQLHPGD | |
| SCHEMBL27890392 | 0.81 | MAPT (0.62) | MAPTSIRT6LMNARECQLHPGD | |
| SCHEMBL11305986 | 0.81 | SIRT6 (0.74) | MAPTSIRT6LMNAHPGDKMT2A | |
| SCHEMBL3381562 | 0.81 | LMNA (0.97) | MAPTSIRT6LMNARECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951153-A1 | SELECTIVE HDAC3 INHIBITORS | Acetylon Pharmaceuticals, Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014121062-A1 | SELECTIVE HDAC3 INHIBITORS | ACETYLON PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |