Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986690 | 0.86 | GAA (0.50) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL3988576 | 0.84 | GAA (0.69) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL3982330 | 0.80 | HPGD (0.47) | BCHEMEN1KMT2ACA12CA1 | |
| SCHEMBL3272134 | 0.79 | GAA (0.91) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL11881258 | 0.79 | GAA (0.91) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL30707909 | 0.78 | LOXL2 (0.36) | MEN1KMT2AALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL27228 | 0.77 | GAA (0.95) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL3982245 | 0.76 | GAA (0.67) | GAAMAPTBCHEMEN1KMT2A | |
| SCHEMBL3040879 | 0.76 | S1PR1 (0.54) | ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL23581968 | 0.75 | GAA (0.91) | GAAMAPTBCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061449-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | Leo Pharma A/S (DK) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019690-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2008-02-21 | — | — | WO | disclosed |