Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SUMO3 | P55854 | 1/20 | 0.44 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244338 | 0.82 | MAOA (0.70) | MAOAMAOBSMN1; SMN2KDM4EHTT | |
| SCHEMBL3976219 | 0.80 | MAOA (0.54) | MAOAMAOBSMN1; SMN2KDM4EHTT | |
| SCHEMBL18608757 | 0.79 | CDC7 (0.52) | KDM4ENPC1HPGDALDH1A1MEN1 | |
| SCHEMBL18434686 | 0.77 | CLK1 (0.42) | HDAC3HDAC1HDAC2HDAC6NPC1 | |
| SCHEMBL11182915 | 0.75 | MAOA (0.51) | MAOAMAOBSMN1; SMN2KDM4EHTT | |
| SCHEMBL2883879 | 0.75 | MAOA (0.49) | MAOAMAOBSMN1; SMN2KDM4EHTT | |
| SCHEMBL28106506 | 0.73 | PDPK1 (0.40) | SMN1; SMN2KDM4EHTTNPC1HPGD | |
| SCHEMBL13574641 | 0.73 | OGA (0.61) | MAOAMAOBALDH1A1MEN1KMT2A | |
| SCHEMBL30078421 | 0.72 | MAOA (0.58) | MAOAMAOBSMN1; SMN2KDM4EHTT | |
| SCHEMBL1310429 | 0.72 | MAOA (0.58) | MAOAMAOBSMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |