Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL106286 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL11481968 | 0.67 | — | — | |
| Phosphine SCHEMBL11857502 | 0.67 | — | — | |
| Phosphine SCHEMBL4445970 | 0.67 | — | — | |
| Phosphine SCHEMBL1943937 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL3322253 | 0.67 | — | — | |
| Phosphine SCHEMBL3672901 | 0.67 | — | — | |
| Ammonia Solution, Strong SCHEMBL11143935 | 0.67 | — | — | |
| Phosphine SCHEMBL12818347 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL9175448 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-54144353-A | — | — | None | — | — | JP | disclosed |
| EP-1299405-B1 | POLYCYCLIC, FUSED RING COMPOUNDS, METAL COMPLEXES AND POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGIES INC (US) | 2009-05-13 | — | — | EP | disclosed |
| US-6800701-B2 | USING COORDINATION CATALYSTS | DOW GLOBAL TECHNOLOGIES INC. | 2004-10-05 | — | — | US | disclosed |
| US-20030216529-A1 | Polycyclic, fused ring compounds, metal complexes and polymerization process | DOW GLOBAL TECHNOLOGIES LLC | 2003-11-20 | — | — | US | disclosed |
| US-6613921-B2 | Ligand comprising at least: a cyclopentadienyl ring, a 6,7,or 8 membered ring other than a 6-carbon aromatic ring, and an aromatic ring; said 6, 7, or 8 membered ring, is fused to both the cyclopentadienyl and the aromatic ring | DOW GLOBAL TECHNOLOGIES INC. | 2003-09-02 | — | — | US | disclosed |
| EP-1299405-A1 | POLYCYCLIC, FUSED RING COMPOUNDS, METAL COMPLEXES AND POLYMERIZATION PROCESS | THE DOW CHEMICAL COMPANY (US) | 2003-04-09 | — | — | EP | disclosed |
| US-20020062011-A1 | Polycyclic, fused ring compounds, metal complexes and polymerization process | DOW GLOBAL TECHNOLOGIES LLC | 2002-05-23 | — | — | US | disclosed |
| WO-2002002577-A1 | POLYCYCLIC, FUSED RING COMPOUNDS, METAL COMPLEXES AND POLYMERIZATION PROCESS | DOW GLOBAL TECHNOLOGY INC. (US) | 2002-01-10 | — | — | WO | disclosed |
| EP-0262227-A1 | Process for the preparation of myoinositol derivatives | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1988-04-06 | — | — | EP | disclosed |
| US-4687874-A | Selective hydroformylation process using alkyl diaryl phosphine rhodium carbonyl hydride catalysts | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1987-08-18 | — | — | US | disclosed |
| US-4687866-A | Ligand exchange process for producing alkyl diaryl phosphine rhodium carbonyl hydrides | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1987-08-18 | — | — | US | disclosed |
| US-4668809-A | ALKYL DIARYLPHOSPHINE RHODIUM CARBONYL HYDRIDES, HYDROFORMYLATION, OLEFINS | EXXON RESEARCH AND ENGINEERING (US) | 1987-05-26 | — | — | US | disclosed |
| US-4595753-A | Nitrogen heterocycle substituted | EXXON RESEARCH AND ENGINEERING CO. (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0024091-B1 | HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1985-04-03 | — | — | EP | disclosed |
| EP-0024091-A4 | HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS. | EXXON RESEARCH ENGINEERING CO (US) | 1981-07-16 | — | — | EP | disclosed |
| EP-0024091-A1 | HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS. | EXXON RESEARCH ENGINEERING CO (US) | 1981-02-25 | — | — | EP | disclosed |
| WO-1980001690-A1 | CARBONYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS | EXXON RESEARCH ENGINEERING CO (US) | 1980-08-21 | — | — | WO | disclosed |
| JP-S54144353-A | 8-EXO-FORMYL-ENDO-TRICYCLO 5,2,1,02,6 DECANE AND PERFUME COMPOSITION COMPRISING IT | KAO CORP | 1979-11-10 | — | — | JP | disclosed |
| US-4018777-A | ANALGESICS, SEDATIVES, ANTICONVULSANTS, TRANQUILIZERS | ABBOTT LABORATORIES (US) | 1977-04-19 | — | — | US | disclosed |