Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991044 | 0.93 | PTGER4 (0.36) | PTGER4FSCN1CNR2PDPK1LIPG | |
| SCHEMBL3984446 | 0.93 | PTGER4 (0.37) | PDE4APDE4BPDE4CPTGER4PDE4D | |
| SCHEMBL3985873 | 0.92 | PTGER4 (0.36) | PDE4APDE4BPDE4CPTGER4FSCN1 | |
| SCHEMBL3986816 | 0.92 | MEN1 (0.42) | PDE4APDE4BPDE4CPTGER4FSCN1 | |
| SCHEMBL3985759 | 0.91 | POLB (0.36) | PTGER4FSCN1CNR2PDPK1LIPG | |
| SCHEMBL3987232 | 0.90 | PTGER4 (0.35) | PTGER4FSCN1CNR2 | |
| SCHEMBL3985290 | 0.90 | CNR2 (0.40) | PDE4APDE4BPDE4CPTGER4PDE4D | |
| SCHEMBL3984637 | 0.90 | ALDH1A1 (0.36) | PTGER4FSCN1CNR2PDPK1LIPG | |
| SCHEMBL3988126 | 0.89 | PTGER4 (0.34) | PTGER4FSCN1CNR2 | |
| SCHEMBL3982488 | 0.88 | PTGER4 (0.33) | PTGER4FSCN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538112-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-05-26 | — | — | US | claimed |
| US-20080287394-A1 | Hiv Integrase Inhibitors | MERCK & CO., INC. (US) | 2008-11-20 | — | — | US | claimed |
| EP-1756114-B1 | HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2014-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287394-A1 | Hiv Integrase Inhibitors | DHPS, DPYD, TYMP | PDE4A 447/4885PDE4B 820/4885PDE4C 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.