Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 5/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523898 | 0.87 | MAPT (0.55) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL4526597 | 0.86 | THRB (0.49) | ALDH1A1KDM4EHPGDGAACYP1A2 | |
| SCHEMBL3990474 | 0.85 | KDM4E (0.47) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3984903 | 0.76 | MAPT (0.44) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL4523894 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3990468 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3993557 | 0.72 | EGFR (0.42) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3990672 | 0.71 | KDM4E (0.58) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3987383 | 0.69 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTHPGDNPC1 | |
| SCHEMBL3994062 | 0.69 | KDM4E (0.55) | ALDH1A1KDM4EMAPTHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035377-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007134864-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2007-11-29 | — | — | WO | disclosed |