Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TACR1 | P25103 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26098590 | 0.79 | RAB9A (0.51) | POLBMEN1KMT2APKMNPC1 | |
| SCHEMBL26103078 | 0.78 | HPGD (0.52) | POLBMEN1KMT2AMMP1MMP3 | |
| SCHEMBL15126028 | 0.77 | POLB (0.61) | POLBMEN1KMT2AHRH3CYP3A4 | |
| SCHEMBL26787011 | 0.76 | POLB (0.57) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9275466 | 0.75 | POLB (0.62) | POLBMEN1KMT2AHRH3CYP3A4 | |
| SCHEMBL9275456 | 0.75 | POLB (0.62) | POLBMEN1KMT2AHRH3CYP3A4 | |
| SCHEMBL21696570 | 0.75 | MEN1 (0.57) | POLBMEN1KMT2AHRH3CYP3A4 | |
| SCHEMBL5741395 | 0.75 | HTT (0.62) | POLBKMT2ATACR1HRH3CYP3A4 | |
| SCHEMBL5741398 | 0.75 | HTT (0.62) | POLBKMT2ATACR1HRH3CYP3A4 | |
| SCHEMBL13374829 | 0.75 | ALDH1A1 (0.74) | POLBMEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059502-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008011392-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACUETICALS INCORPORATED (US) | 2008-01-24 | — | — | WO | disclosed |