Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL4294114 | 0.95 | ALOX15 (0.42) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL4401454 | 0.95 | ALOX15 (0.42) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| D-Glutamate SCHEMBL22833968 | 0.91 | SLC1A3 (0.45) | ALOX15BLMPMP22KMT2ASLC7A5 | |
| Glutamine SCHEMBL17907437 | 0.91 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL17782941 | 0.91 | ALOX15 (0.50) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL5789307 | 0.91 | BLM (0.56) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL28174334 | 0.91 | BLM (0.56) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL1275425 | 0.91 | BLM (0.56) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL727085 | 0.91 | BLM (0.56) | ALOX15BLMPMP22KMT2ASLC1A3 | |
| Glutamine SCHEMBL7707543 | 0.91 | BLM (0.56) | ALOX15BLMPMP22KMT2ASLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682030-A4 | METHODS FOR TREATING DENTAL CONDITIONS USING TISSUE SCAFFOLDS | DENTIGENIX INC (US) | 2009-05-27 | — | — | EP | disclosed |
| US-7309232-B2 | Methods for treating dental conditions using tissue scaffolds | DENTIGENIX INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070248933-A1 | Methods for treating dental conditions using tissue scaffolds | DENTIGENIX INC. (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1682030-A2 | METHODS FOR TREATING DENTAL CONDITIONS USING TISSUE SCAFFOLDS | Dentigenix Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005034789-A2 | METHODS FOR TREATING DENTAL CONDITIONS USING TISSUE SCAFFOLDS | DENTIGENIX INC. (US) | 2005-04-21 | — | — | WO | disclosed |
| US-20050079470-A1 | Methods for treating dental conditions using tissue scaffolds | IVOCLAR VIVADENT, INC. | 2005-04-14 | — | — | US | disclosed |
| US-5885829-A | GROWING VIABLE ORAL TISSUE CELLS ON A SYNTHETIC MATRIX IN VITRO UNDER CONDITIONS EFFECTIVE AND FOR A PERIOD OF TIME SUFFICIENT TO ALLOW PROLIFERATION OF VIABLE ORAL TISSUE CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1999-03-23 | — | — | US | disclosed |