Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.54 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507022 | 0.92 | HRH3 (0.55) | HRH3L3MBTL1MBTD1L3MBTL3SLC6A3 | |
| SCHEMBL18979056 | 0.83 | HRH1 (0.62) | HRH3SLC6A3SIGMAR1KCNH2 | |
| SCHEMBL27928479 | 0.80 | HRH3 (0.60) | HRH3L3MBTL1MBTD1L3MBTL3SLC6A3 | |
| SCHEMBL3326933 | 0.80 | HRH3 (0.67) | HRH3L3MBTL1MBTD1SIGMAR1LSS | |
| SCHEMBL14228422 | 0.80 | HRH3 (0.58) | HRH3L3MBTL1MBTD1L3MBTL3SLC6A3 | |
| SCHEMBL7656308 | 0.77 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL14228241 | 0.77 | KCNH2 (0.55) | HRH3L3MBTL1MBTD1L3MBTL3KCNH2 | |
| SCHEMBL25092863 | 0.76 | HRH3 (0.89) | HRH3L3MBTL1MBTD1L3MBTL3SLC6A3 | |
| SCHEMBL7366528 | 0.76 | HRH3 (0.85) | HRH3L3MBTL1MBTD1L3MBTL3SLC6A3 | |
| Hydrochloric Acid SCHEMBL7675743 | 0.76 | HRH3 (0.68) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |