Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222746 | 0.80 | HSD11B1 (0.62) | HSD11B1NOTUMHSD11B2 | |
| SCHEMBL6543320 | 0.78 | NOTUM (0.57) | ROCK2ROCK1NOTUMAKT1 | |
| SCHEMBL16860860 | 0.78 | ROCK2 (0.52) | ROCK2ROCK1NOTUMAKT1 | |
| SCHEMBL1222044 | 0.76 | HSD11B1 (0.59) | HSD11B1HSD11B2 | |
| SCHEMBL1572534 | 0.75 | NOTUM (0.63) | ROCK2ROCK1NOTUMAKT1 | |
| SCHEMBL30232786 | 0.75 | NOTUM (0.63) | ROCK2ROCK1NOTUMAKT1 | |
| SCHEMBL1222187 | 0.75 | HSD11B1 (0.56) | HSD11B1HSD11B2 | |
| SCHEMBL1223396 | 0.74 | HSD11B1 (0.58) | HSD11B1HSD11B2 | |
| SCHEMBL655024 | 0.74 | NOTUM (0.80) | ROCK2ROCK1NOTUMAKT1 | |
| SCHEMBL4118605 | 0.74 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| EP-2064187-A2 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008024497-A2 | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-02-28 | — | — | WO | disclosed |