Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398806 | 1.00 | NPC1 (0.31) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL398808 | 1.00 | NPC1 (0.31) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL10070593 | 0.91 | — | — | |
| SCHEMBL10070250 | 0.91 | — | — | |
| SCHEMBL10072712 | 0.87 | — | — | |
| SCHEMBL4568667 | 0.71 | S1PR4 (0.39) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL1541425 | 0.69 | SYK (0.32) | — | |
| SCHEMBL1541426 | 0.69 | SYK (0.32) | — | |
| SCHEMBL396650 | 0.68 | S1PR4 (0.41) | NPC1LMNATP53MAPTRAB9A | |
| SCHEMBL30745406 | 0.68 | S1PR4 (0.59) | NPC1LMNATP53MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043646-B1 | (E)-N-{3-(8-Chloro-11H-10-oxa-1-aza- dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-phenyl} -methanesulfonamide as a GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | LILLY CO ELI (US) | 2012-05-16 | — | — | EP | disclosed |
| US-8101760-B2 | Glucocorticoid receptor modulator and methods of use | ELI LILLY AND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100069425-A1 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 2010-03-18 | — | — | US | disclosed |
| EP-2043646-A2 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008882-A2 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069425-A1 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | NR3C1, NR3C2, MC2R | NPC1 409/4885LMNA 4590/4885TP53 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.