Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 8/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522964 | 0.92 | ERN1 (0.43) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL7808468 | 0.84 | LMNA (0.45) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL6136853 | 0.83 | KDM4E (0.44) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL5704931 | 0.81 | MAPT (0.45) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL5704978 | 0.80 | MAPT (0.44) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL27760166 | 0.79 | ESRRG (0.44) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL7807504 | 0.74 | ALDH1A1 (0.37) | ERN1HSD17B1HSD17B2LMNAKDM4E | |
| SCHEMBL1356959 | 0.72 | LMNA (0.70) | ERN1LMNAKDM4EALDH1A1GLA | |
| SCHEMBL3522968 | 0.72 | ALDH1A1 (0.39) | KDM4EALDH1A1GAAMAPTTSHR | |
| SCHEMBL3988284 | 0.72 | BRD4 (0.36) | HSD17B1HSD17B2DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061767-A1 | ARYLAMINOARYL-ALKYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, PROCESSES FOR PREPARING THEM, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THEIR USE | Sanofi-Aventis (FR) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008017381-A1 | ARYLAMINOARYL-ALKYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, PROCESSES FOR PREPARING THEM, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THEIR USE | SANOFI-AVENTIS (FR) | 2008-02-14 | — | — | WO | disclosed |