Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13940576 | 0.96 | ALDH1A1 (0.60) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL3988070 | 0.95 | ALDH1A1 (0.55) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL13940580 | 0.91 | ALDH1A1 (0.58) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL8279855 | 0.89 | TSHR (0.53) | ALDH1A1LMNAGLAELANEGAA | |
| SCHEMBL13940590 | 0.88 | TSHR (0.56) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL3988880 | 0.85 | ALDH1A1 (0.44) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL13940594 | 0.83 | KDR (0.56) | ALDH1A1LMNAGLAATMELANE | |
| SCHEMBL14621243 | 0.82 | TSHR (0.51) | ALDH1A1LMNAGLAATMCYP2C9 | |
| SCHEMBL8334773 | 0.81 | TSHR (0.60) | ALDH1A1ELANEGAARAB9A | |
| SCHEMBL3990363 | 0.81 | KMT2A (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476754-B2 | Biphenyl derived thiamides as calpain inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2009-01-13 | — | — | US | claimed |
| US-20070270480-A1 | Biphenyl Derived Thiamides as Calpain Inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2007-11-22 | — | — | US | claimed |
| EP-1743883-A1 | USE OF BIPHENYL-DERIVED THIAMIDES AS CALPAIN INHIBITORS | Consejo Superior de Investigaciones Cientificas (ES) | 2007-01-17 | — | — | EP | claimed |
| US-7476754-B2 | Biphenyl derived thiamides as calpain inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2009-01-13 | — | — | US | disclosed |
| US-20070270480-A1 | Biphenyl Derived Thiamides as Calpain Inhibitors | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2007-11-22 | — | — | US | disclosed |
| EP-1743883-A1 | USE OF BIPHENYL-DERIVED THIAMIDES AS CALPAIN INHIBITORS | Consejo Superior de Investigaciones Cientificas (ES) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108354-A1 | USE OF BIPHENYL-DERIVED THIAMIDES AS CALPAIN INHIBITORS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270480-A1 | Biphenyl Derived Thiamides as Calpain Inhibitors | CAPN1, CAPN2, CAPNS1 | ALDH1A1 1748/4885LMNA 1817/4885GLA 2934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.