Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 0.39 |
| ▸ | CHUK | O15111 | 4/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989409 | 0.91 | IKBKB (0.46) | IKBKBCHUKTLR9TLR8TLR7 | |
| SCHEMBL14365497 | 0.87 | IKBKB (0.40) | IKBKBCHUKJAK2GPR119JAK1 | |
| SCHEMBL3391151 | 0.87 | GPR119 (0.48) | IKBKBCHUKJAK2GPR119JAK1 | |
| SCHEMBL4418522 | 0.86 | TLR9 (0.40) | IKBKBCHUKTLR9TLR8TLR7 | |
| SCHEMBL3987328 | 0.85 | MAP4K4 (0.39) | IKBKBCHUKTLR9TLR8TLR7 | |
| SCHEMBL3994799 | 0.84 | TLR9 (0.38) | IKBKBCHUKTLR9TLR8TLR7 | |
| SCHEMBL3989890 | 0.84 | TLR9 (0.39) | IKBKBTLR9TLR8TLR7JAK2 | |
| SCHEMBL3994570 | 0.82 | IKBKB (0.41) | IKBKBCHUKTLR9TLR8TLR7 | |
| SCHEMBL3396344 | 0.80 | IKBKB (0.49) | IKBKBCHUKBTKCCNA2CDK2 | |
| SCHEMBL3988315 | 0.77 | TLR9 (0.40) | TLR9TLR8TLR7JAK2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758578-A4 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1758578-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | Smithkline Beecham Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002434-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |