Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 3/20 | 0.35 |
| ▸ | CHUK | O15111 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989409 | 0.88 | IKBKB (0.46) | TLR9TLR8TLR7IKBKBCHUK | |
| SCHEMBL3994799 | 0.86 | TLR9 (0.38) | TLR9TLR8TLR7IKBKBCHUK | |
| SCHEMBL3989210 | 0.86 | IKBKB (0.39) | TLR9TLR8TLR7IKBKBCHUK | |
| SCHEMBL3391862 | 0.86 | GPR119 (0.47) | KDM5AJAK2JAK1CNR1GPR119 | |
| SCHEMBL3987328 | 0.85 | MAP4K4 (0.39) | TLR9TLR8TLR7IKBKBCHUK | |
| SCHEMBL5532791 | 0.85 | IKBKB (0.52) | IKBKBCHUK | |
| SCHEMBL27698208 | 0.84 | RPS6KB1 (0.40) | KDM5ARPS6KB1PDPK1IKBKBCHUK | |
| SCHEMBL3989890 | 0.83 | TLR9 (0.39) | TLR9TLR8TLR7IKBKBJAK2 | |
| SCHEMBL3392932 | 0.81 | IKBKB (0.53) | KDM5ARPS6KB1PDPK1IKBKBCHUK | |
| SCHEMBL3994570 | 0.81 | IKBKB (0.41) | TLR9TLR8TLR7IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758578-A4 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1758578-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | Smithkline Beecham Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002434-A2 | NOVEL INDAZOLE CARBOXAMIDES AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |