Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.41 |
| ▸ | THRA | P10827 | 10/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979678 | 0.83 | THRA (0.56) | THRBTHRAMAPT | |
| SCHEMBL4533982 | 0.82 | THRA (0.38) | THRBTHRAPDE2APDE3BPDE3A | |
| SCHEMBL3981701 | 0.82 | THRA (0.39) | THRBTHRAKDM4EMAPT | |
| SCHEMBL3985944 | 0.82 | THRA (0.39) | THRBTHRAKDM4EMAPT | |
| SCHEMBL3981706 | 0.82 | THRA (0.39) | THRBTHRAKDM4EMAPT | |
| SCHEMBL3975161 | 0.82 | THRA (0.43) | THRBTHRAKDM4EMAPT | |
| SCHEMBL4298149 | 0.79 | THRA (0.46) | THRBTHRAKDM4EMAPT | |
| SCHEMBL3978301 | 0.78 | THRB (0.37) | THRBTHRAPDE2APDE3BPDE3A | |
| SCHEMBL6515823 | 0.77 | KDM4E (0.48) | THRBTHRAKDM4E | |
| SCHEMBL3984721 | 0.76 | KMT2A (0.38) | THRBTHRAPDE2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |
| EP-2024336-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007128492-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2007-11-15 | — | — | WO | disclosed |