Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991259 | 0.94 | BRAF (0.48) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL14266573 | 0.88 | CSF1R (0.54) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL14266603 | 0.88 | CSF1R (0.49) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL14266579 | 0.88 | CSF1R (0.49) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL14266611 | 0.87 | BRAF (0.55) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL14266542 | 0.87 | DDR2 (0.51) | KDRBRAFCSF1RRAF1NPC1 | |
| SCHEMBL5128896 | 0.87 | DNMT3A (0.54) | KDRBRAFCSF1RRAF1DDR2 | |
| SCHEMBL5115902 | 0.86 | CSF1R (0.48) | KDRBRAFCSF1RRAF1DDR2 | |
| SCHEMBL5123391 | 0.86 | RAF1 (0.53) | KDRBRAFCSF1RRAF1KMT2A | |
| SCHEMBL14266595 | 0.85 | RAB9A (0.58) | KDRBRAFCSF1RRAF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061761-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | Millennium Pharmaceuticals, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030448-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |