Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992132 | 1.00 | MAPK1 (0.65) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL18919621 | 0.92 | MAPK1 (0.59) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL18919619 | 0.92 | MAPK1 (0.59) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL18919620 | 0.92 | MAPK1 (0.59) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL16407599 | 0.88 | MAPK1 (0.60) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL27930419 | 0.85 | MAPK1 (0.54) | MAPK1HCAR3MAPTNPSR1CYP3A4 | |
| SCHEMBL27930420 | 0.85 | MAPK1 (0.54) | MAPK1HCAR3MAPTNPSR1CYP3A4 | |
| SCHEMBL22495122 | 0.83 | HCAR3 (0.59) | MAPK1HCAR3MAPTPKMRAB9A | |
| SCHEMBL4910166 | 0.83 | LMNA (0.63) | MAPK1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5857969 | 0.82 | MAPK1 (0.64) | MAPK1MAPTPKMRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778231-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1778231-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020415-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |