Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194004 | 0.89 | TLR8 (0.58) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3991826 | 0.86 | TLR8 (0.70) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3991913 | 0.86 | TLR7 (0.51) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3999203 | 0.81 | ADORA3 (0.54) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL1233657 | 0.80 | TLR7 (0.71) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL5192462 | 0.76 | TLR8 (0.41) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3992822 | 0.75 | ADORA2A (0.46) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL3993609 | 0.75 | TLR8 (0.57) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL30662182 | 0.75 | TLR7 (0.48) | TLR8TLR7ADORA3ADORA2AADORA1 | |
| SCHEMBL21712370 | 0.75 | TLR7 (0.48) | TLR8TLR7ADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696912-A4 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES CO (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1863809-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | Coley Pharmaceutical Group, Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006107753-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-10-12 | — | — | WO | disclosed |
| EP-1696912-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M Innovative Properties Company (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005079195-A2 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |