Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.58 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.58 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 2/20 | 0.56 |
| ▸ | RXRB | P28702 | 2/20 | 0.56 |
| ▸ | RXRG | P48443 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991789 | 0.91 | PTPN1 (0.58) | PTPN1PTPN2PTPN6FOLH1RXRA | |
| SCHEMBL23226557 | 0.90 | PTPN1 (0.61) | PTPN1PTPN2PTPN6RXRARXRB | |
| SCHEMBL4200632 | 0.89 | LRRK2 (0.63) | FOLH1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL11768921 | 0.88 | LRRK2 (0.61) | FOLH1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL1316826 | 0.84 | LRRK2 (0.67) | FOLH1MCL1SYKMRGPRX4LRRK2 | |
| SCHEMBL2451483 | 0.82 | RXRA (0.58) | PTPN1PTPN2PTPN6FOLH1RXRA | |
| SCHEMBL8243758 | 0.82 | LRRK2 (0.58) | PTPN1PTPN2PTPN6FOLH1RXRA | |
| SCHEMBL3998568 | 0.82 | FOLH1 (0.59) | FOLH1MCL1SYKMRGPRX4LRRK2 | |
| SCHEMBL28544263 | 0.81 | RXRA (0.60) | PTPN1PTPN2PTPN6FOLH1RXRA | |
| SCHEMBL3995517 | 0.81 | RXRA (0.60) | PTPN1PTPN2PTPN6RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | TFPI, F3, F2 | PTPN1 1846/4885PTPN2 1843/4885PTPN6 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.