Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.56 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.56 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859259 | 0.86 | SLC7A5 (0.60) | CYP4F2CYP4A11SLC7A5NPC1MAPT | |
| SCHEMBL1788115 | 0.84 | CYP4F2 (0.62) | CYP4F2CYP4A11MEP1BACACBNPSR1 | |
| SCHEMBL7260771 | 0.83 | CYP4F2 (0.61) | CYP4F2CYP4A11MEP1BACACBNPSR1 | |
| SCHEMBL2851334 | 0.81 | FOLH1 (0.54) | MEP1B | |
| SCHEMBL27781443 | 0.80 | CYP4F2 (0.61) | CYP4F2CYP4A11MEP1BNPSR1SLC7A5 | |
| SCHEMBL1198816 | 0.80 | CYP4F2 (0.61) | CYP4F2CYP4A11MEP1BNPC1MAPT | |
| SCHEMBL129801 | 0.79 | CYP4F2 (0.71) | CYP4F2CYP4A11MEP1BNPC1MAPT | |
| SCHEMBL3674764 | 0.78 | CYP4F2 (0.71) | CYP4F2CYP4A11MEP1BNPC1MAPT | |
| SCHEMBL1367640 | 0.78 | CYP4F2 (0.48) | CYP4F2CYP4A11ACACBNPSR1NPC1 | |
| SCHEMBL3995781 | 0.78 | CYP4F2 (0.66) | CYP4F2CYP4A11MEP1BNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064213-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008028617-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-13 | — | — | WO | disclosed |