Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15929467 | 0.83 | IMPDH2 (0.50) | IMPDH2IMPDH1GPR119MEN1KMT2A | |
| SCHEMBL472455 | 0.80 | MAPK14 (0.54) | IMPDH2IMPDH1NPC1RAB9AMAPK14 | |
| SCHEMBL472419 | 0.80 | IMPDH2 (0.47) | IMPDH2IMPDH1GPR119NPC1RAB9A | |
| SCHEMBL472411 | 0.80 | GAA (0.49) | IMPDH2IMPDH1ESR1ESR2GPR119 | |
| SCHEMBL6168845 | 0.80 | IMPDH2 (0.47) | IMPDH2IMPDH1GPR119MEN1KMT2A | |
| SCHEMBL12490774 | 0.78 | IMPDH2 (0.52) | IMPDH2IMPDH1GPR119MEN1KMT2A | |
| SCHEMBL27422553 | 0.78 | IMPDH2 (0.47) | IMPDH2IMPDH1ACHECCNB2CDK1 | |
| SCHEMBL472791 | 0.77 | GSK3B (0.46) | IMPDH2IMPDH1MEN1KMT2ANPC1 | |
| SCHEMBL12491024 | 0.77 | IMPDH2 (0.51) | IMPDH2IMPDH1GPR119MEN1KMT2A | |
| SCHEMBL472518 | 0.76 | IMPDH2 (0.47) | IMPDH2IMPDH1GPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009075960-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |