Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998459 | 0.83 | IMPDH2 (0.50) | IMPDH2IMPDH1PKMMEN1KMT2A | |
| SCHEMBL472455 | 0.83 | MAPK14 (0.54) | IMPDH2IMPDH1NOTUMNPC1MAPK14 | |
| SCHEMBL472411 | 0.83 | GAA (0.49) | IMPDH2IMPDH1NOTUMLMNAMEN1 | |
| SCHEMBL6168845 | 0.83 | IMPDH2 (0.47) | IMPDH2IMPDH1LMNAMEN1KMT2A | |
| SCHEMBL472419 | 0.83 | IMPDH2 (0.47) | IMPDH2IMPDH1LMNANPC1MAPK14 | |
| SCHEMBL343219 | 0.83 | ADORA2A (0.50) | IMPDH2IMPDH1NOTUMLMNANPC1 | |
| Methane SCHEMBL17941330 | 0.82 | IMPDH2 (0.46) | IMPDH2IMPDH1LMNAMEN1KMT2A | |
| SCHEMBL8066719 | 0.81 | MAPK14 (0.56) | NOTUMLMNAPKMMEN1KMT2A | |
| SCHEMBL472791 | 0.80 | GSK3B (0.46) | IMPDH2IMPDH1LMNAMEN1KMT2A | |
| SCHEMBL472451 | 0.79 | NOTUM (0.47) | IMPDH2IMPDH1NOTUMALDH1A1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067224-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-03-10 | — | — | US | disclosed |
| US-9220710-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140221421-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067224-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | IMPDH2 459/4885IMPDH1 172/4885NOTUM 1713/4885 |
| US-20140221421-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | IMPDH2 459/4885IMPDH1 172/4885NOTUM 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.