Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25191423 | 0.81 | ACE (0.36) | KMT2AMEN1ACEP2RX7 | |
| SCHEMBL25191422 | 0.81 | ACE (0.36) | KMT2AMEN1ACEP2RX7 | |
| SCHEMBL3998764 | 0.81 | TSHR (0.36) | TSHRGAAL3MBTL1ELANEKMT2A | |
| SCHEMBL16584604 | 0.80 | EPHX2 (0.36) | THRB | |
| SCHEMBL1270274 | 0.77 | MAPT (0.37) | TSHRGAAELANEKMT2AMEN1 | |
| SCHEMBL903473 | 0.77 | MAPT (0.37) | TSHRGAAELANEKMT2AMEN1 | |
| SCHEMBL2581443 | 0.73 | P2RX7 (0.49) | L3MBTL1KMT2AACEP2RX7 | |
| SCHEMBL2581442 | 0.73 | P2RX7 (0.49) | L3MBTL1KMT2AACEP2RX7 | |
| SCHEMBL2954476 | 0.71 | ACE (0.54) | TSHRGAAL3MBTL1THRBATM | |
| SCHEMBL10367039 | 0.71 | POLB (0.37) | TSHRGAAPOLBL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |