Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903473 | 0.83 | MAPT (0.37) | TSHRMAPTALDH1A1TP53KDM4E | |
| SCHEMBL1270274 | 0.83 | MAPT (0.37) | TSHRMAPTALDH1A1TP53KDM4E | |
| SCHEMBL3998769 | 0.81 | TSHR (0.36) | TSHRTP53L3MBTL1MEN1GAA | |
| SCHEMBL25191422 | 0.78 | ACE (0.36) | MAPTHTTMEN1KMT2A | |
| SCHEMBL25191423 | 0.78 | ACE (0.36) | MAPTHTTMEN1KMT2A | |
| SCHEMBL2954472 | 0.73 | ACE (0.42) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL29191657 | 0.71 | ALDH1A1 (0.39) | MAPTALDH1A1TP53KDM4EMEN1 | |
| SCHEMBL14486939 | 0.71 | ALDH1A1 (0.40) | TSHRMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL18396801 | 0.71 | PPM1B (0.43) | MAPTALDH1A1KDM4EGAAALOX15 | |
| SCHEMBL4005436 | 0.70 | FKBP1A (0.36) | MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |