Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPYD | Q12882 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4001516 | 0.77 | CHUK (0.38) | PDPK1ALDH1A1 | |
| SCHEMBL3991545 | 0.74 | ERCC5 (0.36) | DPYDALDH1A1POLBKMT2ATDP1 | |
| SCHEMBL3999236 | 0.72 | KDM5A (0.34) | DPYDMCL1 | |
| SCHEMBL3997496 | 0.71 | DPYD (0.36) | DPYDALDH1A1MCL1 | |
| SCHEMBL15850383 | 0.66 | DYRK1A (0.36) | DPYDALDH1A1 | |
| SCHEMBL4942622 | 0.65 | MCL1 (0.35) | DPYDMCL1 | |
| SCHEMBL3996464 | 0.65 | TMIGD3 (0.39) | DPYDALDH1A1POLB | |
| SCHEMBL16201663 | 0.63 | PDPK1 (0.33) | PDPK1 | |
| SCHEMBL3997640 | 0.63 | DPYD (0.38) | DPYDALDH1A1KMT2AMCL1 | |
| SCHEMBL15850393 | 0.62 | IMPDH2 (0.39) | DPYDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066675-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | Wyeth (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008039414-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | WYETH (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080076926-A1 | Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles | WYETH | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076926-A1 | Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles | MAP4K2, MAP4K1, MAP4K3 | DPYD 514/4885PDPK1 121/4885ALDH1A1 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.