Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | DPYD | Q12882 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997496 | 0.80 | DPYD (0.36) | MCL1DPYDKDM5A | |
| SCHEMBL3996464 | 0.77 | TMIGD3 (0.39) | DPYDKDM5A | |
| SCHEMBL3993861 | 0.71 | KDM4E (0.46) | MCL1 | |
| SCHEMBL3995033 | 0.69 | HPGD (0.39) | MCL1 | |
| SCHEMBL3999236 | 0.69 | KDM5A (0.34) | MCL1DPYDKDM5A | |
| SCHEMBL3997640 | 0.67 | DPYD (0.38) | MCL1DPYD | |
| SCHEMBL15850393 | 0.66 | IMPDH2 (0.39) | MCL1DPYD | |
| SCHEMBL18332827 | 0.65 | DPYD (0.43) | MCL1DPYDKDM5A | |
| SCHEMBL3999985 | 0.65 | DPYD (0.36) | MCL1DPYD | |
| SCHEMBL4847045 | 0.62 | GRM6 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937690-A1 | THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007038519-A1 | THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-04-05 | — | — | WO | disclosed |