Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Captopril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 7/20 | 1.00 |
| ▸ | REN | P00797 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | LTA4H | P09960 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PEPD | P12955 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Captopril SCHEMBL7983782 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL675797 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444049 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL678794 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL1913521 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2422871 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| D-Captopril SCHEMBL2444053 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2786691 | 1.00 | ACE (1.00) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL5556542 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA | |
| Captopril SCHEMBL2489188 | 0.98 | ACE (0.97) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 72891 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4743449-A1 | L-ARGININE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| EP-4743450-A1 | L-LYSINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| EP-4743451-A1 | TROMETHAMINE SALT OF 4-CHLORO-5-[4-(2,6-DICHLOROPHENYL)SULFONYLPIPERAZIN-1-YL]-1-BENZOFURAN-2-CARBOXYLIC ACID AND VARIOUS FORMS THEREOF | ENYO Pharma (FR) | 2026-05-20 | — | — | EP | claimed |
| CN-122059859-A | Synthesis method of diaryl methyl sulfide under biocompatible condition | 南京工业大学 | 2026-05-19 | — | — | CN | claimed |
| EP-4739293-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS | AZURA OPHTHALMICS LTD (IL) | 2026-05-13 | — | — | EP | claimed |
| EP-4739291-A2 | ADMINISTRATION OF KERATOLYTICS TO OCULAR AND PERIOCULAR SURFACES | AZURA OPHTHALMICS LTD (IL) | 2026-05-13 | — | — | EP | claimed |
| CN-122010656-A | Application of oxyalkylisourea in introducing methyl and isotopically-labeled methyl | 陕西师范大学 | 2026-05-12 | — | — | CN | claimed |
| US-20260124148-A1 | POLYPEPTIDE FORMULATIONS FOR ORAL DELIVERY | BHAMIS RES LABORATORY PVT LTD (IN) | 2026-05-07 | — | — | US | claimed |
| EP-0072868-A1 | CYCLODEXTRIN CLATHRATE COMPOUNDS OF SULFUR-CONTAINING COMPOUNDS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-03-02 | — | — | EP | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0055870-A1 | Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | claimed |
| US-4332726-A | Purification of mercaptoacyl amino acids | E. R. SQUIBB & SONS, INC. (US) | 1982-06-01 | — | — | US | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | claimed |
| US-4307099-A | Reaction products of pyrazolo[1,5-c]quinazoline derivatives and proline derivatives and methods for reducing blood pressure while inhibiting allergic reactions with them | E. R. SQUIBB & SONS, INC. (US) | 1981-12-22 | — | — | US | claimed |
| US-4297282-A | REACTING AN A-METHYL-B-ACYLTHIOPROPIONIC ACID WITH AN OPTICALLY ACTIVE ARYLALKYL PRIMARY AMINE; CRYSTALLIZATION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1981-10-27 | — | — | US | claimed |
| EP-0036145-A1 | An orally administered drug form comprising a polar bioactive agent and an adjuvant | INTERx RESEARCH CORPORATION (US) | 1981-09-23 | — | — | EP | claimed |
| EP-0031561-A2 | A rectally administered suppository comprising a drug and an adjuvant | MERCK & CO. INC. (US) | 1981-07-08 | — | — | EP | claimed |